A study published recently in the British Journal of Nutrition has found that supplementation with the probiotic L. rhamnosus encourages weight loss in overweight women.
A group of 125 overweight men and women were placed on a calorie restricted diet for 12 weeks, followed by a further 12-weeks of a ‘weight maintenance’ diet. While half of the participants were given a placebo supplement, the other half were given two capsules of L rhamnosus probiotic supplements at a total daily dosage of 1.6 billion L rhamnosus bacteria.
Both body weight and body composition were measured at the beginning of the study and then at 12 and 24 weeks. The probiotic supplement did not appear to affect weight loss in the men at all. However, the effect of probiotics on the women in the study was more marked. Compared to the women in the placebo group, those women taking probiotics experienced significantly more weight loss at the 12-week mark. While the placebo group managed a loss of 2.6 kg, those women on probiotics experienced an average loss of 4.4 kg.
After 12 weeks, all of the women were placed on a weight maintenance diet. As expected, the women in the placebo group maintained their original weight loss. In contrast, the women in the probiotic group continued to lose weight and body fat, losing an average of 5.2 kg by the end of the study. These women were also found to have lower levels of circulating leptin, a hormone that helps to regulate appetite and satiety.
It is particularly interesting that the women taking the probiotic continued to lose weight despite eating at maintenance. The study’s results suggest that the L. rhamnosus strain may encourage metabolic changes that favour weight loss. The researchers suggest that probiotics may act by altering the permeability of the intestinal wall. Because probiotics can prevent certain proinflammatory molecules from entering the bloodstream, they might therefore help prevent the chain reaction that leads to glucose intolerance, type 2 diabetes, and obesity. This mechanism of action suggest that other strains of probiotics could have a similar effect. Indeed other studies have encountered similar successful results with probiotics such as lactobacillus fermentum, lactobacillus amylovorus, akkermansia muciniphila and lactobacillus gasserei (2-4).
It is not clear why the rhamnosus probiotic appeared to benefit the women but not the men in the study. The researchers suggested that the men may have needed a higher dose or a longer period of supplementation.
Clearly maintaining a healthy weight requires a healthy, balanced diet. For those wanting to lose weight, this study suggests that a probiotic supplement may encourage weight loss and healthy metabolic changes when used alongside a healthy, balanced diet. The link between probiotics and weight loss is a particularly fascinating one, and hopefully this study will encourage further research in this area.
Sanchex M et al (2014) Effect of Lactobacillus rhamnosus CGMCC1.3724 supplementation on weight loss and maintenance in obese men and women B J NutrApr 28;111(8):1507-19.
Omar et al (2012). Lactobacillus fermentum and Lactobacillus amylovorus as probiotics alter body adiposity and gut microflora in health persons. Journal of Functional Foods.
Everard A et al (2013) Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. PNAS 110:22, 9066-9071.
Reference: Kadooka, Y. et al; ‘Regulation of abdominal adiposity by probiotics (Lactobacillus gasseri SBT2055) in adults with obese tendencies in a randmomized controlled trial.’ European Journal of Clinical Nutrition., June 2010, Vol. 64, No. 6, Pp. 636-643.