Tag Archives: omegaflex duo

Optimising supplements for managing joint pain and inflammation

Osteoarthritis is the most common cause of musculo-skeletal disability in the elderly and, within the secondary care system, its management is primarily focused on palliative relief using pharmaceutical drugs such as non-steroidal anti-inflammatory drugs (NSAIDs) and analgesics. As with many pharmaceutical drugs, there are potential side effects, with treatment regimens also failing to address the progressive and complex nature of the condition.

The potential role of pharmaconutrients
Not surprisingly, given the safety profile of the majority of nutritional interventions, practitioners are continually striving to identify disease-modifying pharmaconutrients that are capable of both improving symptoms and preventing, slowing, or even reversing the degenerative process. Clinically, osteoarthritis is characterised by joint pain, crepitus (grating or cracking sounds on movement), stiffness after immobility and general limited movement. Identifying nutrients that can aid and support these symptoms are crucial to providing both relief from pain and treating the condition itself [1, 2].

Fatty acids as immunomodulators
Marine omega-3 fatty acids such as eicosapentaenoic acid (EPA) and the omega-6 fatty acid gamma-linolenic acid (GLA) exhibit anti-inflammatory effects through the production of eicosanoids – substances with both anti-inflammatory and immunoregulatory properties. As such, both are well documented as useful natural agents to help treat inflammatory diseases, alone and in combination.

Gamma-linolenic acid
GLA is found in certain plant-seed oils, including evening primrose seed oil, and is metabolised to dihomo-gamma-linolenic acid (DGLA) the direct precursor to anti-inflammatory and immunoregulatory products. Supplemental GLA has been shown to suppress acute and chronic inflammation in several conditions, including arthritis [3].

Omegaflex Duo
Omegaflex Duo is one supplement that combines glucosamine, calcium and EPA which is beneficial for bone health.

Eicosapentaenoic acid
The specific ratio of the principal omega-3 and omega-6 fatty acids AA (arachidonic acid) and EPA provides valuable information on the measure of the body’s eicosanoid balance and the AA:EPA ratio provides a direct indication of the inflammatory state of the body. Developing an anti-inflammatory treatment regime means preventing or reducing the accumulation of AA from the diet. By reducing AA through EPA supplementation, we reduce the substrate for the formation of inflammatory eicosanoids and increase the production of anti-inflammatory eicosanoids directly from EPA. Interestingly, whilst the benefits of EPA as a potent anti-inflammatory and immune-regulating fatty acid are well established, [4] these benefits are significantly superior for osteoarthritis sufferers when combined with glucosamine [5].

Glucosamine
As well as pain and joint degeneration, osteoarthritis also involves progressive loss of cartilage. Glucosamine is an amino monosaccharide believed to stimulate production of compounds called glycosaminoglycans and proteoglycans, the ‘building blocks’ of cartilage. Whilst glucosamine is important as a structural component, it is also known to exert specific pharmacologic effects by decreasing the production of inflammatory products. Glucosamine does this by regulating their production at the genetic level, by switching off genes that are directly involved in their production, thereby interfering with the inflammatory signalling cascade. When administered exogenously, it is used for the treatment of osteoarthritis as a prescription drug or a dietary supplement [6].

Calcium
The synovial fluid within joints contains calcium, as does the cartilage lining the joints. When that calcium crystallises, the resulting tiny shards wear away the joint surface and spur the release of enzymes that further break down cartilage. Not surprisingly, it is sometimes thought that because osteoarthritis is aggravated by calcium deposition in joints, osteoarthritis patients should avoid taking calcium. Formation of calcium crystals can, however, result in calcium deficiency and, whilst calcium serves to maintain healthy bones and teeth, it is also essential for the normal functioning of muscles, blood vessels and nerves. If proper management of calcium is not carried out, this could be harmful for osteoarthritis patients, who may be at a higher risk of also developing osteoporosis, especially if they are long-term users of NSAIDs [7].

 

Written by Dr Nina Bailey

References
1. Lopez HL: Nutritional interventions to prevent and treat osteoarthritis. Part I: focus on fatty acids and macronutrients. PM & R : the journal of injury, function, and rehabilitation 2012, 4:S145-154.
2. Lopez HL: Nutritional interventions to prevent and treat osteoarthritis. Part II: focus on micronutrients and supportive nutraceuticals. PM & R : the journal of injury, function, and rehabilitation 2012, 4:S155-168.
3. Dawczynski C, Hackermeier U, Viehweger M, Stange R, Springer M, Jahreis G: Incorporation of n-3 PUFA and gamma-linolenic acid in blood lipids and red blood cell lipids together with their influence on disease activity in patients with chronic inflammatory arthritis–a randomized controlled human intervention trial. Lipids in health and disease 2011, 10:130.
4. Calder PC: Omega-3 polyunsaturated fatty acids and inflammatory processes: Nutrition or pharmacology? British journal of clinical pharmacology 2012.
5. Gruenwald J, Petzold E, Busch R, Petzold HP, Graubaum HJ: Effect of glucosamine sulfate with or without omega-3 fatty acids in patients with osteoarthritis. Advances in therapy 2009, 26:858-871.
6. Rovati LC, Girolami F, Persiani S: Crystalline glucosamine sulfate in the management of knee osteoarthritis: efficacy, safety, and pharmacokinetic properties. Therapeutic advances in musculoskeletal disease 2012, 4:167-180.
7. Vestergaard P, Rejnmark L, Mosekilde L: Fracture risk associated with use of nonsteroidal anti-inflammatory drugs, acetylsalicylic acid, and acetaminophen and the effects of rheumatoid arthritis and osteoarthritis. Calcified tissue international 2006, 79:84-94.

 

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An introduction to Igennus

Igennus – Where It All Began…

It’s not always easy to see the positive during a crisis – let alone an opportunity – but this was exactly how the seed of an idea for a specialist nutrition business was planted in the mind of Igennus Healthcare Nutrition’s Founder and CEO, Dr Jav Nazemi.

In 1998, Jav’s family experienced a health scare with their youngest daughter, who was diagnosed with a rare heart condition. This left her with a damaged and narrowed heart valve, which caused blood clots that subsequently caused blind spots in her vision.

Not wanting to rely on lifelong prescriptions of penicillin and aspirin, the family avidly researched how good diet and nutrition could help to manage their daughter’s condition. Jav spoke to Hammersmith clinician Professor Basant Puri (an eminent researcher, author and proponent of nutritional medicine) for advice. Professor Basant was doing research on Fish Oils and getting remarkable results. This was the start of a journey that led to the formation of Igennus Healthcare Nutrition – a company founded on the principles of holistic health and nutritional science.

The  Igennus Family of Products

E-EPA 90E-EPA 90 - Restore Wellbeing – Step 1

E-EPA 90 is the purest ethyl-EPA concentrate available without prescription, suitable for counteracting omega-3 deficiencies and restoring a healthy omega-6 to omega-3 ratio. Research suggests that EPA plays an important role in supporting optimum brain function, including attention, concentration and emotional wellbeing.

Vegepa E-Epa 70Vegepa E-EPA 70 - Maintain Wellbeing – Step 2

Vegepa combines the benefits of 70% ethyl-EPA concentrate extracted from marine anchovy oil with GLA and triterpene antioxidants from organic virgin evening primrose oil. This unique formulation balances and maintains healthy omega-3 and omega-6 levels, providing cells with essential nutrients to support efficient brain function and emotional wellbeing.

Vegepa ChewablesVegepa E-EPA 70 Orange Chewables - From Age 3+

Vegepa Chewables combine the benefits of 70% ethyl-EPA concentrate extracted from marine anchovy oil with GLA and triterpene antioxidants from organic virgin evening primrose oil. This unique formulation balances and maintains healthy omega-3 and omega-6 levels, providing cells with essential nutrients to support brain function, including attention and concentration. These child-friendly capsules are sugar-free, sweetened with natural xylitol and flavoured with sweet orange oil.

EchiomegaEchiomega – Suitable for Vegetarians and Vegans

Echiomega Echium Seed Oil (sourced from Echium plantagineum) provides the richest natural source of the omega-3 SDA, offering support for cardiovascular health and eye function, maintaining anti-inflammatory and immune response, and promoting healthy skin.  Echium Seed Oil offers the highest rate of conversion of any plant-derived omega-rich oil to the important long-chain fatty acid EPA, making Echiomega an ideal supplement for vegetarians and vegans.

Omegaflex DuoOmegaFlex Duo - Replenish & Repair joints and bones

Omegaflex DUO is an advanced multi-action formula for the joints and bones, combining the powerful natural anti-inflammatory properties of ethyl-EPA and GLA with the tissue-restoring properties of glucosamine & bioavailable calcium, vitamins C & D3 and minerals.  These vital nutrients nourish the synovial fluid, support collagen synthesis and form the building blocks for cartilage and bone tissue renewal, as well as offering direct anti-inflammatory support. These natural and synergistic ingredients are highly bioavailable – using a special form of hypoallergenic glucosamine (non-shellfish-derived) and ‘pre-digested’ algae-derived calcium for optimum absorption and utilisation in the body.

Commitment to efficacy, quality and sustainability

Igennus has carved out a specialist expertise in the area of polyunsaturated fatty acids and its relevance to a wide range of health concerns. From the very beginning, Igennus has pioneered the use of pure EPA for preventative and restorative health. Igennus’ lead product Vegepa E-EPA 70 now has a dedicated and loyal following, with thousands of customers taking daily doses of pure EPA for inflammatory conditions and ailments ranging from CFS, psoriasis, arthritis and diabetes to depression, ADHD and schizophrenia.

Research and development are central to the innovation of Igennus’ specialist EPA supplements, which are developed in association with nutrition scientists and independent researchers and clinicians. The provision of efficacious supplements and a relentless focus on quality and safety are key – a company-wide commitment that influences choice of suppliers, raw materials, packaging facilities and even testing labs. All products are independently batch-tested to guarantee safety and are certified free from heavy metals, PCBs and dioxins. Igennus EPA is sourced from sustainable marine anchovies, with minimal impact on biodiversity.

Igennus won’t compromise on using natural ingredients, and avoid artificial colours, flavours, preservatives and sweeteners at all costs – a commitment that has its challenges, but something Igennus is committed to for the long term.

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