Tag Archives: obesity

Probiotic Lactobacilus rhamnosus aids weight loss in overweight women

A study published recently in the British Journal of Nutrition has found that supplementation with the probiotic L. rhamnosus encourages weight loss in overweight women.

Weight Loss
A probiotic supplement may encourage weight loss and healthy metabolic changes when used alongside a healthy, balanced diet.

A group of 125 overweight men and women were placed on a calorie restricted diet for 12 weeks, followed by a further 12-weeks of a ‘weight maintenance’ diet. While half of the participants were given a placebo supplement, the other half were given two capsules of L rhamnosus probiotic supplements at a total daily dosage of 1.6 billion L rhamnosus bacteria.

Both body weight and body composition were measured at the beginning of the study and then at 12 and 24 weeks. The probiotic supplement did not appear to affect weight loss in the men at all. However, the effect of probiotics on the women in the study was more marked. Compared to the women in the placebo group, those women taking probiotics experienced significantly more weight loss at the 12-week mark. While the placebo group managed a loss of 2.6 kg, those women on probiotics experienced an average loss of 4.4 kg.

After 12 weeks, all of the women were placed on a weight maintenance diet. As expected, the women in the placebo group maintained their original weight loss. In contrast, the women in the probiotic group continued to lose weight and body fat, losing an average of 5.2 kg by the end of the study. These women were also found to have lower levels of circulating leptin, a hormone that helps to regulate appetite and satiety.

It is particularly interesting that the women taking the probiotic continued to lose weight despite eating at maintenance. The study’s results suggest that the L. rhamnosus strain may encourage metabolic changes that favour weight loss. The researchers suggest that probiotics may act by altering the permeability of the intestinal wall. Because probiotics can prevent certain proinflammatory molecules from entering the bloodstream, they might therefore help prevent the chain reaction that leads to glucose intolerance, type 2 diabetes, and obesity. This mechanism of action suggest that other strains of probiotics could have a similar effect. Indeed other studies have encountered similar successful results with probiotics such as lactobacillus fermentum, lactobacillus amylovorus, akkermansia muciniphila and lactobacillus gasserei (2-4).

It is not clear why the rhamnosus probiotic appeared to benefit the women but not the men in the study. The researchers suggested that the men may have needed a higher dose or a longer period of supplementation.

Clearly maintaining a healthy weight requires a healthy, balanced diet. For those wanting to lose weight, this study suggests that a probiotic supplement may encourage weight loss and healthy metabolic changes when used alongside a healthy, balanced diet. The link between probiotics and weight loss is a particularly fascinating one, and hopefully this study will encourage further research in this area.

References

Sanchex M et al (2014) Effect of Lactobacillus rhamnosus CGMCC1.3724 supplementation on weight loss and maintenance in obese men and women B J NutrApr 28;111(8):1507-19.

Omar et al (2012). Lactobacillus fermentum and Lactobacillus amylovorus as probiotics alter body adiposity and gut microflora in health persons. Journal of Functional Foods.

Everard A et al (2013) Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. PNAS 110:22, 9066-9071.

Reference: Kadooka, Y. et al; ‘Regulation of abdominal adiposity by probiotics (Lactobacillus gasseri SBT2055) in adults with obese tendencies in a randmomized controlled trial.’ European Journal of Clinical Nutrition., June 2010, Vol. 64, No. 6, Pp. 636-643.

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Fibre and Obesity

It is widely known that levels of obesity across the world have been rising at a staggering rate over the past few decades. We can’t miss the constant references to junk food and obesity in the news, however our obesogenic environments seem to present people with barriers to losing weight and becoming healthier.

Wholegrain Bread contains fibre
Foods like wholegrain bread contains fibre which could be good for a healthy weight and BMI.

It is important to overcome these barriers as the rises in overweight and obesity have been directly linked to low intakes of fibre rich foods such as vegetables, fruit, whole-grains and legumes (i.e. under the recommended intake of 18-30 grams of fibre a day in the UK).

Likewise, higher intakes of fibre are correlated with lower body mass index (BMI) and reduced incidence of metabolic disturbances such as hypertension, heart disease and diabetes. Fibre may also help to induce satiety, balance blood sugar and prevent hunger pangs and cravings which in turn can help to reduce energy intake, which offers another potential benefit for overweight individuals.

In order to investigate the effect of overweight individuals’ fibre intake in particular, one study (1) compared the fibre intakes from healthy diet, supplementation or a placebo on body composition and other metabolic measures. This study, published in the British Journal of Nutrition, aimed to discover the effects of additional fibre intakes on metabolic outcomes and also to determine the amount of fibre that would be the most effective. The study used four groups where subjects either consumed a placebo powder (breadcrumbs) with their usual diet (control), a fibre supplement in the form of 12g of psyllium husks with their usual diet, a healthy eating diet with placebo and finally healthy eating diet with fibre supplementation. The researchers found that compared to the control group, who simply ate their usual diet with a placebo, the subjects in all groups increased their daily fibre intakes. Specifically, the healthy eating diet with psyllium husk supplementation group increased their fibre intake by a massive 39g a day, which was in comparison to an 11g increase for health eating alone.

The authors noted that the addition of the fibre supplement to a normal diet was enough to produce improvements in weight, BMI and % body fat. However, they stated that it is the combination of a healthy diet with fibre supplementation that produced the greatest improvements in all bodily measures (including total cholesterol, LDL cholesterol, insulin, body weight and BMI) for overweight individuals. This led the authors to conclude that an intake of fibre above 30g per day from both dietary sources and fibre supplements was the most suitable for those who are overweight, and not simply the adoption of a healthy diet alone. Therefore, if you are interested in losing weight, increasing your health and reducing your risks of metabolic conditions, you may wish to include the following high fibre foods into your diet along with fibre supplements such as psyllium, rice bran, wheat bran etc:

– Vegetables; including split peas (around 8g of fibre per 100g).

– Seeds; for example flax seeds provide 2.7g of fibre per tablespoon.

– Cereals; e.g a medium size bowl of All-Bran contains 9.8g of fibre; Two pieces of Shredded Wheat contain 4.3g of fibre; Two Weetabix contain 3.6g of fibre.

– Legumes such as red kidney beans; three tablespoons of red kidney beans contain 5.4g of fibre.

– Fruits such as apricots; three whole apricots contain 5g of fibre; Three whole prunes contain 4.6g of fibre and a medium size pear (with skin) contains 3.7g of fibre.

Written by Lauren Foster

References

(1) Pal, S. Khossousi, A., Binns, C., Dhaliwal, S. & Ellis, V. (2011). The effect of a fibre supplement compared to a healthy diet on body composition, lipids, glucose, insulin and other metabolic syndrome risk factors in overweight and obese individuals. British Journal of Nutrition, 105, 90100.

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Could Probiotics help with Weight Management?

Some research exists to suggest that probiotics could help with weight management – but how would that work, and how sound is the research?

In 2006, a seminal study[1] published in the well-respected journal, Nature, showed a clear difference in the gut bacteria of obese people as opposed to their lean counterparts. What’s more, when obese participants later lost weight, their gut bacteria reverted back to those observed in lean participants.

Since then, smaller studies continue to support the theory that gut bacteria could influence weight. In 2009, a trial[2] found that women who took Lactobacillus & Bifidobacterium probiotics during pregnancy and breastfeeding were less likely to be obese 6 months following birth. 25% of the women who had received dietary advice alongside probiotic supplementation had excess abdominal fat, as opposed to in 43% of women who had received dietary advice with a placebo.

Weight Loss
Weight Loss may be supported by a higher probiotic bacteria balance in the gut

Could we be doing more to fight the obesity epidemic?

In 2010, a double-blind, randomised placebo-controlled trial in Japan[3] found a Lactobacillus probiotic to reduce abdominal fat by 4.6% and subcutaneous fat (just below the skin) by 3.3%. The trial recruited 87 overweight participants and randomly assigned a daily dose of fermented milk either with or without the probiotics, for a period of 12 weeks. The probiotic group given milk containing the probiotic Lactobacillus gasseri SBT2055, showed significant decreases in body weight BMI, in waist circumference, and in the hips.

How could Probiotics encourage Weight Loss?

No one knows for certain just yet, but mechanisms could include:

  • Better breakdown of foods (a well understood benefit of probiotics).
  • Displacement of pathogenic bacteria associated with weight gain.
  • Stimulating the body’s production of natural substances associated with decreased body fat.
  • L. acidophilus was found in a small study in 2008[5] to increase the body’s production of leptin (a protein commonly accepted to decrease appetite and increase metabolism) and to result in weight loss.
  • In 2010 scientists in Ireland found another Lactobacillus probiotic to influence the fat composition of the host, via production of the fatty acid t10, c12 CLA; a molecule previously associated with decreased body fat.
  • Correlation between obesity & digestive health issues such as constipation. Fascinating ongoing research in the USA by Dr Mark Pimental suggests that those with constipation could be absorbing more calories, potentially because when the gut performs at a slower rate the body has more time to absorb calories.[6] As probiotics could help to support bowel regularity (especially well-researched strains such as Bifidobacterium lactis BB-12Ò [7],[8]), a more efficient digestive process could lead to fewer calories being absorbed.

Moving Forward

In England our rates of obesity have doubled over the last 25 years, with 60% of adults overweight or obese today[9]. Any natural support in tackling this obesity epidemic could therefore play a fundamental role in the future. Currently evidence remains too sparse for any firm conclusions, although the results certainly look promising. Of course we needn’t tell you that taking a holistic approach and also looking at diet, fitness and exercise is always to be encouraged.

For individuals looking to lose weight a high quality daily probiotic might be suggested. For daily wellbeing EXTRA Strength contains 20 billion high quality Lactobacillus & Bifidobacteria probiotics. L. acidophilus NCFM is thought to be the most researched strain of acidophilus in the world which can be found in this probiotic supplement.

 

References:

1.Bajzer, M, & Seeley, R. ‘Phsyiology: Obesity and Gut Flora.’ Nature, 2006, Vol. 444, pp.1009 -1010.

2.News release, 17th European Congress on Obesity. 17th European Congress on obesity meeting, Amsterdam, Netherlands, May 6-9, 2009.

3. Y. Kadooka et al., ‘Regulation of abdominal adiposity by probiotics (Lactobacillus gasseri SBT2055) in adults with obese tendencies in a randomised controlled trial.’ European Journal of Clinical Nutrition, 2010, vol. 64, No. 6, pp.636-643.

4. Rosberg-Cody, E. ‘Recombinant Lactobacilli expressing linolic acid isomerise can modulate the fatty acid composition of host adipose tissue in mice’. Microbiology, Dec, 22, 2012 DOI: 10. 1099/mic.0.043406-0.

5. R. Sousa et al., ‘Effect of Lactobacillus acidophilus supernatants on body weight and leptin expression in rats’. BMC Complementary and Alternative Medicine, 2008, 8:5 doi: 10.1186/6882-8-5.

6. BBC Radio 4, Tuesday 8th March 2011 2100-2130h ‘Programme no. 9 – gut bacteria’ Radio science unit. Presented by Mark Porter; contributors: Glenn Gibson, Christine Edwards, Thomas Broody, Alisdair Macchonnachie, Mark Pimentel & Ian Rowland.

7. Matsumoto, M. et al. (2001) Effect of yoghurt with Bifidobacterium lactis BB-12 in improving fecal microflora and defecation of healthy volunteers. Journal of Intestinal Microbiology; 14(2): pp.97-102.

8. Pitkala, K, H. et al. (2007) Fermented cereal with specific Bifidobacteria normalises bowel movements in elderly nursing home residents. A randomised, controlled trial. Journal of Nutriitonal Health and Ageing; 11.(4): pp.305-311.

9. guardian.co.uk/sustainable-business/food-companies-health-wellbeing

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