Tag Archives: body fat

Probiotic Lactobacilus rhamnosus aids weight loss in overweight women

A study published recently in the British Journal of Nutrition has found that supplementation with the probiotic L. rhamnosus encourages weight loss in overweight women.

Weight Loss
A probiotic supplement may encourage weight loss and healthy metabolic changes when used alongside a healthy, balanced diet.

A group of 125 overweight men and women were placed on a calorie restricted diet for 12 weeks, followed by a further 12-weeks of a ‘weight maintenance’ diet. While half of the participants were given a placebo supplement, the other half were given two capsules of L rhamnosus probiotic supplements at a total daily dosage of 1.6 billion L rhamnosus bacteria.

Both body weight and body composition were measured at the beginning of the study and then at 12 and 24 weeks. The probiotic supplement did not appear to affect weight loss in the men at all. However, the effect of probiotics on the women in the study was more marked. Compared to the women in the placebo group, those women taking probiotics experienced significantly more weight loss at the 12-week mark. While the placebo group managed a loss of 2.6 kg, those women on probiotics experienced an average loss of 4.4 kg.

After 12 weeks, all of the women were placed on a weight maintenance diet. As expected, the women in the placebo group maintained their original weight loss. In contrast, the women in the probiotic group continued to lose weight and body fat, losing an average of 5.2 kg by the end of the study. These women were also found to have lower levels of circulating leptin, a hormone that helps to regulate appetite and satiety.

It is particularly interesting that the women taking the probiotic continued to lose weight despite eating at maintenance. The study’s results suggest that the L. rhamnosus strain may encourage metabolic changes that favour weight loss. The researchers suggest that probiotics may act by altering the permeability of the intestinal wall. Because probiotics can prevent certain proinflammatory molecules from entering the bloodstream, they might therefore help prevent the chain reaction that leads to glucose intolerance, type 2 diabetes, and obesity. This mechanism of action suggest that other strains of probiotics could have a similar effect. Indeed other studies have encountered similar successful results with probiotics such as lactobacillus fermentum, lactobacillus amylovorus, akkermansia muciniphila and lactobacillus gasserei (2-4).

It is not clear why the rhamnosus probiotic appeared to benefit the women but not the men in the study. The researchers suggested that the men may have needed a higher dose or a longer period of supplementation.

Clearly maintaining a healthy weight requires a healthy, balanced diet. For those wanting to lose weight, this study suggests that a probiotic supplement may encourage weight loss and healthy metabolic changes when used alongside a healthy, balanced diet. The link between probiotics and weight loss is a particularly fascinating one, and hopefully this study will encourage further research in this area.

References

Sanchex M et al (2014) Effect of Lactobacillus rhamnosus CGMCC1.3724 supplementation on weight loss and maintenance in obese men and women B J NutrApr 28;111(8):1507-19.

Omar et al (2012). Lactobacillus fermentum and Lactobacillus amylovorus as probiotics alter body adiposity and gut microflora in health persons. Journal of Functional Foods.

Everard A et al (2013) Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. PNAS 110:22, 9066-9071.

Reference: Kadooka, Y. et al; ‘Regulation of abdominal adiposity by probiotics (Lactobacillus gasseri SBT2055) in adults with obese tendencies in a randmomized controlled trial.’ European Journal of Clinical Nutrition., June 2010, Vol. 64, No. 6, Pp. 636-643.

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New Evidence for Green Coffee Extract and Weight Loss

A new study suggests that green coffee extract may be an effective supplement in aiding weight loss (1). The supplement was linked with substantial weight loss, decreased body fat, and a decrease in blood pressure over the short study period.

The research, published in the journal Diabetes, Metabolic Syndrome and Obesity, followed a group of 16 adults over a course of 22 weeks.

Green Coffee Extract may help weight
Green Coffee Extract may help weight management (4.)

Each participant was overweight or obese, and aged between 22 and 26 years. The study used a high dose capsule (1050mg), a low dose capsule (700mg) and a placebo. The study was a “cross-over” design, meaning that participants cycled through the dose active doses and the placebo, taking each for 6 weeks. Each person essentially acted as his or her own “control”, meaning that the study results were more likely to be accurate and meaningful.

The diets of the participants were monitored throughout. “Their calories, carbohydrates, fats and protein intake did not change during the study, nor did their exercise regimen change,” study leader Vinson said. On average, the participants were eating around 2400 calories per day.

The subjects lost an average of 17 pounds over the course of the study. This was equal to 10.5% of their overall body weight. Each participant also lost an average of 16% body fat. Telephone interviews conducted 4 months after the study ended found that 14 of the 16 subjects had maintained their weight loss.

The caffeine in the supplement is unlikely to have contributed to the result. In total, the supplements provided up to 20mg caffeine – about the amount in a regular cup of coffee.

The active ingredient in the supplement actually appears to be chlorogenic acid. This is a compound naturally present in green coffee which acts as a strong anti-oxidant, quenching free oxygen radicals. Chlorogenic acid has been found to slow down the absorption of fat from the intestine and to activate fat metabolism in the liver (2). It also inhibits sugar absorption and influences glucose metabolism (3). Chlorogenic acid breaks down when coffee beans are roasted, meaning that drinking regular coffee will not offer the same benefits.

The design of the study used only a short break between each ‘cycle’, where the subjects swapped between supplements, and this may have affected the result. Despite this limitation, the authors concluded that the green coffee supplement may be “an effective neutraceutical in reducing weight in preobese adults, and may be an inexpensive means of preventing obesity in overweight adults.”

Written by Nadia Mason, BSc MBANT NTCC CNHC

References

1. Vinson J, Burnham B, Nagendran MV (2012) Randomized, double-blind, placebo-controlled, linear dose, crossover study to evaluate the efficacy and safety of a green coffee bean extract in overweight subjects. Diabetes Metab Syndr Obes. 5: 21-27.

2. Shimoda H, Seki E, Aitani M (2006) Inhibitory effect of green coffee bean extract on fat accumulation and body weight gain in mice. BMC Complement Altern Med 17;6:9.

3. Narita Y, Inouye K. (2009) Kinetic analysis and mechanism on the inhibition of chlorogenic acid and its components against porcine pancreas alpha-amylase isozymes I and II. J Agric Food Chem. 14;57(19):9218-25.

4. Image courtesy of Foto76

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