Tag Archives: anti-oxidant

Alpha-lipoic acid improves blood sugar control in diabetics

A new double-blind controlled study suggests that alpha lipoic acid supplementation may benefit patients with type 2 diabetes (1). Type 2 diabetes is the more common form of the condition, accounting for around 90% of diabetes sufferers.

Researchers investigated the effect of alpha lipoic acid supplements on glycemic control and oxidative status of 38 diabetic patients over a period of 6 months.

Alpha Lipoic Acid may help combat type 2 diabetes.
Alpha Lipoic Acid can help increase levels of antioxidants

Alpha-lipoic acid is a naturally occurring antioxidant that is present in every cell in the body. Its function is to help turn glucose into energy. It can help to increase insulin sensitivity and glucose uptake. In fact, previous clinical studies in humans have demonstrated improvement in insulin sensitivity in patients with type 2 diabetes after supplementation with alpha lipoic acid (2).

Another benefit of alpha lipoic acid is that it can help to increase or maintain levels of other antioxidants including COQ 10, vitamin C, vitamin E and glutathione. This may be of benefit to diabetic patients because this condition leads to increased need for antioxidant protection. Even when diabetes sufferers are able to control their blood sugar well, they are still at risk of other complications as a result of raised levels of free radicals. Complications can include peripheral neuropathy, scar tissue formation and inflammation.

For these reasons, the researchers believe that the antioxidant properties of alpha lipoic acid may offer an additional benefit to diabetes patients.

The thirty-eight volunteers were randomly assigned to receive an alpha lipoic acid supplement (in doses of 300, 600, 900 or 1200 mg/day) or a placebo for 6 months. Each patient was instructed to take their supplement 30 minutes before meals.

All of the patients were receiving standard medical care for their condition, and were either taking prescribed drugs for diabetes, or following a prescribed diet.

After the 6-month period, all patients underwent blood tests to assess glucose levels and signs of oxidation.

The results showed that fasting blood glucose levels were lower in patients who had received alpha lipoic acid. Levels of substances called PGF2α-Isoprostanes, a product of oxidative stress, were also measured. These levels were lower in the alpha lipoic acid group, suggesting that this group also had lower levels of oxidative damage.

The supplements were monitored for safety, and were found to be well tolerated. The researchers state however that a larger test group may be needed to clarify the study’s results.

In the UK, numbers of people diagnosed with diabetes have doubled in the last ten years, and these figures continue to rise (3). Hopefully this study will pave the way for further research into natural adjuncts to standard treatment, to help improve quality of life for those affected.

Written by Nadia Mason, BSc MBANT NTCC CNHC.

References

1.Porasuphatana S, Suddee S, Nartnampong A, Konsil J, Harnwong B, Santaweesuk A. Glycemic and oxidative status of patients with type 2 diabetes mellitus following oral administration of alpha-lipoic acid: a randomized double-blinded placebo-controlled study. Asia Pac J Clin Nutr. 2012;21(1):12-21.

2.Kamenova P. Improvement of insulin sensitivity in patients with type 2 diabetes mellitus after oral administration of alpha-lipoic acid. Hormones (Athens). 2006;5:251-8.

3.Diabetes UK. Diabetes in the UK 2012: Key statistics on diabetes.

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UK Falls Short on Vitamin Intake

It is 100 years since the discovery of vitamins by Polish scientist Casimir Funk. A century later, are we managing to meet our recommended intake of these vital nutrients? A study published last month in the British Journal of Nutrition suggests that we are not (1).

The study, a review of national dietary surveys, has highlighted shortfalls in the Western diet, with adults in the UK likely to be deficient in critical nutrients such as Vitamins D and E.

The researchers reviewed the diets of adults in the UK, Germany, the Netherlands and the USA, and compared them with national recommendations. Data was taken from the more recent national dietary intake surveys from each country as a basis for the analysis.

Of the countries studies, the Netherlands appeared healthiest, with fewer significant vitamin shortfalls compared with the rest of Europe and the US. Data from the UK and the USA showed similar patterns and levels of deficiencies, perhaps reflecting similar dietary habits and lifestyles.

Data from the UK included dietary information for both men and women between the ages of 19 and 49 years old. The results showed that more than 75% of men and women in the UK are deficient in Vitamins D and E, Furthermore, between 50-75% of UK adults are deficient in Vitamin A. Up to 50% of UK women were also found to fall short of the recommended dietary intake of certain B Vitamins such as folic acid and riboflavin.

Fruit Bowl
Fruit can help to maintain your vitamin levels.

The researchers concede that “a gap exists between vitamin intakes and requirements for a significant proportion of the population, even though diverse foods are available.” Increases in the consumption of fast food with low nutritional value probably accounts for this ‘gap’. A diet based on nutrient-dense, organic, whole foods is the best way to meet your nutritional requirements. A healthy diet should also be free from added sugar, refined grains and alcohol which ‘rob’ the body of nutrients.

Dr Manfred Eggersdorfer, DSM Senior Vice-President for Nutrition and Science Advocacy, and one of the study’s authors, concludes that action is needed to ensure that we are getting the vitamins we need for optimal health.  “This research highlights that 100 years after the discovery [of vitamins], there are still major gaps that urgently need closing – to improve people’s long term health and to drive down healthcare costs.”

Failing to meet the recommended levels of vitamins can leave individuals vulnerable to a host of chronic, diet-related diseases. In the UK in particular,  the recent study shows that many are failing to obtain adequate levels of Vitamins A, C and E in our diets. As these vitamins are major antioxidant nutrients, then, this could mean that a large number of the UK population are vulnerable to oxidative damage which is linked to the progression of a huge range of conditions from accelerated ageing and inflammation to cataracts, hypertension and diabetes.

Changing lifestyles mean that, even with the best of intentions, we do not always have the time or opportunity to ensure that we are getting all the nutrients we need from our diet. Processed convenience foods are all too readily available. Furthermore, unavoidable factors such as stress and pollution increase our nutrient needs. Small dietary changes can help to redress the balance. Regular consumption of oily fish, eggs and brightly coloured vegetables will help deliver a balanced of Vitamin A and its precursor beta-carotene, while regular snacks of fresh fruit and raw nuts and seeds will provide Vitamins C and E. For those in need of additional support, a good quality multi-vitamin or antioxidant supplement will help close the gap between vitamin intakes and recommendations.

Written by Nadia Mason, BSc MBANT NTCC CNHC

References

1. Troesch et al (2012) Dietary surveys indicate vitamin intakes below recommendations are common in representative Western countries. Brit J Nutr 108:4, pp. 692-698.

2. Image courtesy of  lynnc

 

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