A new double-blind controlled study suggests that alpha lipoic acid supplementation may benefit patients with type 2 diabetes (1). Type 2 diabetes is the more common form of the condition, accounting for around 90% of diabetes sufferers.
Researchers investigated the effect of alpha lipoic acid supplements on glycemic control and oxidative status of 38 diabetic patients over a period of 6 months.
Alpha-lipoic acid is a naturally occurring antioxidant that is present in every cell in the body. Its function is to help turn glucose into energy. It can help to increase insulin sensitivity and glucose uptake. In fact, previous clinical studies in humans have demonstrated improvement in insulin sensitivity in patients with type 2 diabetes after supplementation with alpha lipoic acid (2).
Another benefit of alpha lipoic acid is that it can help to increase or maintain levels of other antioxidants including COQ 10, vitamin C, vitamin E and glutathione. This may be of benefit to diabetic patients because this condition leads to increased need for antioxidant protection. Even when diabetes sufferers are able to control their blood sugar well, they are still at risk of other complications as a result of raised levels of free radicals. Complications can include peripheral neuropathy, scar tissue formation and inflammation.
For these reasons, the researchers believe that the antioxidant properties of alpha lipoic acid may offer an additional benefit to diabetes patients.
The thirty-eight volunteers were randomly assigned to receive an alpha lipoic acid supplement (in doses of 300, 600, 900 or 1200 mg/day) or a placebo for 6 months. Each patient was instructed to take their supplement 30 minutes before meals.
All of the patients were receiving standard medical care for their condition, and were either taking prescribed drugs for diabetes, or following a prescribed diet.
After the 6-month period, all patients underwent blood tests to assess glucose levels and signs of oxidation.
The results showed that fasting blood glucose levels were lower in patients who had received alpha lipoic acid. Levels of substances called PGF2α-Isoprostanes, a product of oxidative stress, were also measured. These levels were lower in the alpha lipoic acid group, suggesting that this group also had lower levels of oxidative damage.
The supplements were monitored for safety, and were found to be well tolerated. The researchers state however that a larger test group may be needed to clarify the study’s results.
In the UK, numbers of people diagnosed with diabetes have doubled in the last ten years, and these figures continue to rise (3). Hopefully this study will pave the way for further research into natural adjuncts to standard treatment, to help improve quality of life for those affected.
Written by Nadia Mason, BSc MBANT NTCC CNHC.
1.Porasuphatana S, Suddee S, Nartnampong A, Konsil J, Harnwong B, Santaweesuk A. Glycemic and oxidative status of patients with type 2 diabetes mellitus following oral administration of alpha-lipoic acid: a randomized double-blinded placebo-controlled study. Asia Pac J Clin Nutr. 2012;21(1):12-21.
2.Kamenova P. Improvement of insulin sensitivity in patients with type 2 diabetes mellitus after oral administration of alpha-lipoic acid. Hormones (Athens). 2006;5:251-8.
3.Diabetes UK. Diabetes in the UK 2012: Key statistics on diabetes.